<?php
function loseSpace($pcon){
    $pcon = preg_replace("/ /","",$pcon);
    $pcon = preg_replace("/&nbsp;/","",$pcon);
    $pcon = preg_replace("/　/","",$pcon);
    $pcon = preg_replace("/\r\n/","",$pcon);
    $pcon = str_replace(chr(13),"",$pcon);
    $pcon = str_replace(chr(10),"",$pcon);
    $pcon = str_replace(chr(9),"",$pcon);
    return $pcon;
}
?>

var_dump("            开头有空格          中间 有空格 中间有换行符 \r\n 结束有空格 ");

var_dump(loseSpace("            开头有空格          中间 有空格 中间有换行符 \r\n 结束有空格 "));